Angina Pectoris is a condition that presents itself as pain felt on the chest area that is the result of myocardial ischemia. Myocardial Ischemia is often a result of an imbalance between the supply of oxygen to the heart muscle and the heart’s demand for oxygen.
The causes of the ischemia may vary and this results to a cascade of reactions within the Cardiac muscle. In the absence of oxygen, the myocardial cells initiate the use of anaerobic respiration and vital heart functions begin to deteriorate. Metabolic, electrical, and mechanical functions of cardiac cells become impaired and the heart progressively deteriorates.
The most common presenting symptom of Angina Pectoris is Angina, or in lay man’s term, chest pain. It has been noted that Adenosine may be the main chemical mediator responsible for this pain. When Ischemia occurs, ATP is reduced into Adenosine and it causes arteriolar dilation and anginal pain.
Heart disease is the leading cause of death worldwide for both men and women. 785,000 Americans have their first coronary attack every year The total cost of heart disease burden has been estimated to be $108.9 billion in the USA alone.