There is one drug that some lay people mix with astringents to come up with a “mixture” of a solution to be applied topically. This drug is Clindamycin. Is it the proper way of using the drug to treat pimples?

Clindamycin Drug Study

Generic Name: Clindamycin hydrochloride
Brand Name: Dalacin-C, Cleocin
Classification: Antibiotic, lincosamide


  1. Treatment of serious respiratory tract infections caused by anaerobes
  2. Treatment of serious skin and soft tissue infections, septicemia and abdominal infections
  3. Serious infections caused by Streptococci/ Staphylocicci/ Pneumococci
  4. Adjunct to surgery for chronic bone/joint infections
  5. Treatment of acne vulgaris
  6. Treatment of bacterial vaginosis


  1. Suppresses protein synthesis by microorganisms by binding to ribosomes
  2. Prevents peptide formation
  3. Does not diffuse adequately to the CSF


  1. Hypersensitivity
  2. Use in treating minor bacterial infections
  3. Use in clients with a history of regional enteritis, ulcerative colitis, meningitis, antibiotic-associated colitis
  4. Use for treating viral infections
  5. Lactation

Special Concerns:

  1. Systemic use may cause severe and possibly fatal colitis.
  2. Diarrhea and pseudomembranous colitis may occur up to several weeks.
  3. Opiates or diphenoxylate with atropine may aggravate the condition.
  4. Reserve for serious infections.


  1. Diarrhea
  2. Pseudomembranous colitis
  3. Tinnitis
  4. Nausea and vomiting
  5. Slin rashes
  6. Dry skin
  7. Burning
  8. Itching
  9. Skin erythema
  10. Peeling
  11. Oily skin
  12. Cardiopulmonary arrest
  13. Anaphylaxis
  14. Agranulocytosis
  15. Aplastic anemia


Per Orem: 150-300mg q6h. For severe infections: 300-450mg q6h.
Life-threatening infections: 4.8 grams/IV
Topical: Apply a thin film on the affected area.

Nursing Considerations:

  1. Use parenteral form for anaerobic infections
  2. Reduce dosage in severe renal impairment
  3. Give parenteral dosage for hospitalized clients only
  4. Administer IV over 20-60 minutes
  5. Assess for diarrhea and possible colitis
  6. Assess extent of infections and if improvement occurs
  7. Monitor liver and renal function
  8. With IV, keep in bed for 30 min. following infusion to prevent hypotension
  9. Take orally with a full glass of water to prevent stomach distress
  10. If diarrhea occurs, do not use antiperistaltic agents
  11. If using vaginal cream, it weakens latex-containing condoms due to the mineral oil content
  12. Do not use peeling agents on affected acne areas
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