Generic Name: Omeprazole
Classifications:gastrointestinal agent; proton pump inhibitor
Availability: 10 mg, 20 mg, 40 mg capsules
An antisecretory compound that is a gastric acid pump inhibitor. Suppresses gastric acid secretion by inhibiting the H+, K+-ATPase enzyme system [the acid (proton H+) pump] in the parietal cells.
Suppresses gastric acid secretion relieving gastrointestinal distress and promoting ulcer healing.
Duodenal and gastric ulcer. Gastroesophageal reflux disease including severe erosive esophagitis (4 to 8 wk treatment). Long-term treatment of pathologic hypersecretory conditions such as Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis. In combination with clarithromycin to treat duodenal ulcers associated with Helicobacter pylori.
Long-term use for gastroesophageal reflux disease, duodenal ulcers; lactation.
Route & dosage
Gastroesophageal Reflux, Erosive Esophagitis, Duodenal Ulcer
adult: PO 20 mg once/d for 4–8 wk
adult: PO 20 mg b.i.d. for 4–8 wk
adult:PO 60 mg once/d up to 120 mg t.i.d.
Duodenal Ulcer Associated with H. pylori
adult:PO 40 mg once/d for 14 d, then 20 mg/d for 14 d, in combination with clarithromycin 500 mg t.i.d. for 14 d
Give before food, preferably breakfast; capsules must be swallowed whole (do not open, chew, or crush).
Note: Antacids may be administered with omeprazole.
Assessment & Drug Effects
- Lab tests: Monitor urinalysis for hematuria and proteinuria. Periodic liver function tests with prolonged use.
Patient & Family Education
- Report any changes in urinary elimination such as pain or discomfort associated with urination, or blood in urine.
- Report severe diarrhea; drug may need to be discontinued.
- Do not breast feed while taking this drug.