Meninges are delicate membranes surrounding the brain and the spinal cord. These membranes protect the brain by housing a fluid-filled space. In cases where the meninges are inflamed and infection took place either by viral, bacterial, or fungal causes, meningitis takes place. Commonly, meningitis is bacterial or viral in nature and the infection started elsewhere in the body such as in the upper respiratory tract, the ears, or in the sinuses.
Types and Causes of Meningitis
As mentioned above, meningitis is the inflammation and infection of the brain’s delicate membrane – the meninges. It can be classified as aseptic, septic, and tuberculosis. Aseptic meningitis is referred to as either viral meningitis or the occurrence of meningeal irritation is due to brain abscess, encephalitis, lymphoma, leukemia, or blood in the subarachnoid space. When meningeal infection is caused by bacteria such meningococcus, staphylococcus or influenza bacillus it is classified as aseptic meningitis. If it is caused by tubercle bacillus, it is classified as tuberculosis meningitis.
Meningeal infection, bacterial in nature, tends to be contagious. Those that are caused by a virus are less severe and patients recover completely from the condition. The rarest form of this disease, fungal meningitis, only affects individuals with a weak immune system.
Compared to bacterial meningitis, the viral type is less serious. The condition is caused by certain viruses even those that cause diarrhea. Most individuals affected with the viral type recover completely from the condition.
This is the rarest form and as suggested by its name, it is a fungal-related infection. It is rare among healthy individuals, however, immunosuppressed people such as those diagnosed with AIDS are more likely to become infected.
This is the most significant form of meningitis and the bacteria frequently accounted in 75% of the cases are:
- Neisseria Meningitidis (meningococcal meningitis)
- Streptococcus Pneumoniae (in adults)
- Haemophilus Influenzae (in children and young adults)
Infection in this type of meningitis is transmitted via direct contact. This means that if an infected person coughs or sneezes, the bacteria can be transferred to another individual. Not all exposed to the bacteria develop the disease, some of them become carriers only.
- Upper respiratory tract infections
- Otitis media
- Sickle cell anemia
- Head trauma
- Recent neurosurgical procedures
- Immunologic defects
Bacterial meningitis begins as an infection in the oropharynx then septicemia takes place extending to the meninges of the brain and upper part of the spinal cord. In normal physiology, the venous channels of the posterior nasopharynx, the middle ear and the mastoid drain to the brain. The enumerated parts are also located near the veins draining in the meninges, hence if any of them are infected bacteria can easily proliferate the brain’s protective membrane.
As the organism enters the bloodstream, it causes meninges to produce inflammatory reactions. This results in further inflammation of the underlying cortex and can cause thrombosis and reduces the blood flow in the cerebral area. Metabolically, the cerebral tissue is impaired due to meningeal exudate, vasculitis, and hypoperfusion. Furthermore, this exudate may spread over to the base of the brain and even the spinal cord. Inflammation can also spread to the linings of the cerebral ventricles. The result is alterations in intracranial physiology manifested by cerebral edema, increasing permeability of the blood-brain barrier, and increased intracranial pressure (ICP).
- Headache – this is an initial symptom of meningitis and is usually severe. Headache is caused by meningeal irritation.
- Fever – patient’s body temperature remains high throughout the course of illness.
- Alteration in the patient’s Level of Consciousness – in the early course of the condition, the patient becomes disoriented and has impaired memory. As the condition progresses, the patient can become lethargic, unresponsive, and later on develop coma.
- Irritation of the meninges
- Nuchal rigidity (stiff neck) – this is an early sign of the condition and is caused a spasm in the muscles of the neck. It is difficult for the affected individual to flex the head due to this condition. Any forceful flexion causes extreme pain.
- Positive Kernig’s Sign – this is a distinct physical demonstrable symptom of meningitis characterized by severe stiffness of the hamstrings causing the inability of the patient to straighten the leg when the hip is flexed to 90 degrees.
- Positive Brudzinki’s sign – this is another distinct physical symptom of this condition where the patient’s knees and hips are flexed when flexion of the neck is done.
- Increased ICP – the signs of increased ICP are widened pulse pressure, bradycardia, and irregularity in respirations, headache, vomiting, and depressed level of consciousness.
- Antibiotic therapy. Before antibiotics are prescribed, cerebrospinal fluid and blood cultures are secured then antimicrobial therapy is started immediately. Some medications prescribed to diagnosed individuals are penicillin, ampicillin, or chloramphenicol.
- Fluid Volume Expanders. Dehydration or shock is treated with this.
- Diazepam or Phenytoin. This is administered for seizures.
- Mannitol. May be used to manage cerebral edema.
If someone in the family manifests the signs and symptoms of meningitis enumerated above, medical care should be sought right away. Although viral meningitis can improve without changes, the bacterial type is serious and progresses quickly. Delayed treatment can increase an individual’s risk of brain damage or worst death.